Product Description

Description

Forever Health^TM Slim Support contains vitamins that are essential to the proper conversion of food into energy, including vitamins C, E, and B6, Thiamin, Riboflavin, Niacin, Biotin, and Molybdenum. In addition, Slim Support includes a combination of high-quality nutrients that aid metabolic function.

Research

Chromium

Chromium Picolinate, a bio-available form of chromium, is an essential trace element that has glucose-balancing effects to fight cravings and balance weight. Chromium levels are often lower in individuals with insulin weaknesses suggesting balanced amounts are needed to maintain blood sugar levels.[1]

A review of 15 clinical trials found significant improvement in insulin levels was correlated with Chromium Picolinate.[2] One study recruited 37 patients with insulin ailments to take Chromium Picolinate with an insulin drug or placebo with an insulin drug. Researchers found that adding Chromium Picolinate to insulin therapy significantly balanced glucose levels, improved insulin sensitivity, and lessened body weight and fat accumulation.[3]

An animal study found Chromium Picolinate improved insulin function in obese rats suggesting this mineral is a valuable aid in managing weight.[4] In addition, Chromium Picolinate significantly improved carbohydrate and lipid metabolism in rats with insulin ailments.[5]

Cinnamon

Cinnamon is a small tree grown in India, Sri Lanka, and Brazil, and is one of the oldest known spices. One teaspoon of cinnamon contains a healthy dose of manganese, calcium, fiber, and iron. This potent spice provides many health benefits such as: aiding digestion, improving circulation, increasing energy, and regulating blood sugar.[6]

Cinnamon extract was administered to overweight patients in a water-soluble form to determine the effects on blood sugar and body composition. Researchers found that cinnamon significantly improved body composition and glucose levels. It was suggested that cinnamon may decrease insulin and cardiovascular risks associated with weight problems.[7]

A group of researchers studied the effects of cinnamon extract on blood sugar levels after eating a meal. Healthy subjects were recruited to consume rice pudding with or without cinnamon. Subjects that consumed the rice pudding (300 mg) and cinnamon (6 mg) had a lower glucose response, then subjects that did not consume cinnamon.[8]

A six-week study found that cinnamon extract improved glucose and insulin levels in mice with blood sugar ailments. Researchers suggested that these effects could be associated with cinnamon’s ability to suppress high glucose levels and slow the absorption of carbohydrates in the small intestine.[9] Additionally, cinnamon extract was administered to rats fed a high-fructose diet for three weeks. Results indicated that cinnamon extract improved insulin regulation, when compared to the placebo group. Researchers suggested cinnamon extract could enhance insulin signaling to stabilize blood sugar.[10]

Garcinia Cambogia (Super Citrimax®***)

As a pumpkin-shaped fruit, native to India, Garcinia Cambogia contains Hydroxycitric Acid, a natural compound that is effective in suppressing the appetite and reducing fat accumulation. A study published in Current Therapeutic Research saw a 5-6% decline in body weight and BMI after 8 weeks of treatment.[11]

Various animal studies have reviewed the effects of Garcinia Cambogia on metabolic function. The progression of inflammation, oxidative stress, and insulin resistance was observed in overweight rats. Researchers discovered these unhealthy factors were lower in rats treated with Garcinia Cambogia compared to the placebo group.[12] Similarly, a three-month treatment observed the effects of Garcinia Cambogia on body weight in rats finding a significant reduction in body weight was achieved in the treatment group, when compared to the placebo.[13] The effect of Garcinia Cambogia on excessive lipid formation was also reviewed discovering HDL cholesterol levels and accumulation of adipose tissue decreased in rats.[14]

Green Tea

Green Tea is rich in catechin polyphenols, particularly epigallocatechin gallate (EGCG), which has thermogenic and fat oxidizing capabilities. Green Tea has been an effective aid for fat oxidation, weight management, and insulin sensitivity.[15]

Men and women with excessive visceral fat were given Green Tea for 12 weeks finding a decrease in fat and overall body weight was greater than the control group.[16]

Glucose tolerance and fat oxidation were measured in moderate-intensity exercise subjects taking Green Tea extract. Results indicated fat oxidation levels (17%) and glucose sensitivity (13%) were higher after taking Green Tea extract, when compared to the placebo.30

Combining Green Tea extract with an exercise routine increased fat oxidation in the liver and skeletal muscles, and decreased weight in mice consuming a high-fat diet.[17] Furthermore, Green Tea extract stimulated fat oxidation to improve exercise endurance capacity in mice. Researchers indicated exercise endurance was 30% higher in mice taking Green Tea extract, as metabolic capacity and fat utilization increased to improve skeletal muscle energy.[18], [19]

Gymnema Sylvestre

Gymnema sylvestre, a woody, vine-like plant found in India, contains gymnemic acids that are active compounds for managing weight and blood sugar levels.[20]

The active compounds that are found in Gymnema Sylvestre reduced blood glucose levels in mice.[21] A three-week animal study found Gymnema Sylvestre influenced lipid metabolism by balancing cholesterol levels in rats fed a high-fat or normal-fat diet.[22] A similar study found Gymnema Sylvestre reduced circulating fat and cholesterol to benefit weight management.[23]

Furthermore, Gymnema Sylvestre has been shown to suppress sugar-cravings, as its active compounds are similarly shaped to sugar molecules lessening the need to taste sweet or bitter foods.[24]

Hoodia Gordonii

Hoodia Gordonii, a cactus grown in South Africa, was used by San Bushmen of the Kalahari desert to suppress appetite during long hunting excursions. Hoodia Gordonii contains P57, a molecular compound that helps the hypothalamus think the stomach is full.

Animal studies have found Hoodia reduced appetite in lean and obese rats. Overweight rats experienced significant weight loss, while lean rats had a moderate suppression of appetite.[25] Furthermore, Hoodia was compared to a weight loss drug finding food consumption and weight greatly decreased in rats taking Hoodia. In comparison, the weight loss drug slightly suppressed appetite, but did not decrease body weight.[26]

L-Carnitine (L-Carnipure®)

L-CarniPure®, also known as L-Carnitine, is an essential amino acid in the fat burning process. Crucial to transporting long-chain fatty acids through mitochondria, L-Carnitine also moves stored body fat and triglycerides into the bloodstream to be used for energy. It is synthesized in the kidneys and liver by lysine and methionine, two essential amino acids, and resides mainly in the muscle tissue.

One study observed the effects of L-CarniPure® on long-chain fatty acid oxidation in healthy adults with 1 gram per t.i.d for 10 days. Results showed an increase in fat oxidation among subjects receiving L-CarniPure®; therefore, L-CarniPure® aided fat metabolism.[27]

Another study sustained these findings suggesting L-CarniPure significantly influenced fat oxidation in overweight subjects. Subjects that received 3 gram per d of L-CarniPure® for 10 days had an increase in fat oxidation, in other words the fat stored in the body was used efficiently for energy.[28]

Additional Information – Dosage & Interactions

Suggested Use

As a dietary supplement, take three capsules daily, or as directed by a physician.

Dosage

Chromium – 50 to 200 mcg per day

Cinnamon – Up to 4,000 mg per day

Garcinia Cambogia (Super Citrimax®***) – Up to 1,000 mg per serving

Green Tea – Up to 500 mg per day (200 mg EGCG, NMT 200 mg caffeine)

Gymnema Sylvestre – 200 to 250 mg per day

Hoodia Gordonii – Up to 200 mg per serving

L-Carnitine – Up to 2,000 mg per day in divided doses

Precautions

The maximum safe dosages of the supplements in this formula have not been determined for children, pregnant or nursing women, or those with severe liver or kidney disease. As with all supplement regimens, please consult your physician prior to use.

Chromium – There are no known adverse reactions with proper supplementation.

Cinnamon – There are no known adverse reactions with proper supplementation.

Garcinia Cambogia (Super Citrimax®***) – There are no known adverse reactions with proper supplementation.

Green Tea – Excessive amounts of caffeine can lead to restlessness, tremors, etc.

Gymnema Sylvestre – Individuals with diabetes should consult a physician before taking products with Gymnema Sylvestre.

Hoodia Gordonii – There are no known adverse reactions with proper supplementation.

L-Carnitine – L-Carnitine is generally well tolerated, although some individuals have reported mild gastrointestinal symptoms.

Drug Interactions

If you are insulin-dependent or taking drugs to lower your blood glucose levels, please talk to your physician prior to taking Slim Support.

Chromium – Beta-Blockers (may elevate cholesterol levels)

Cinnamon – There are no known interactions with proper supplementation.

Garcinia Cambogia (Super Citrimax®***) – There are no known interactions with proper supplementation.

Green Tea – Blood thinners, alkaline medications

Gymnema Sylvestre – Blood-sugar medications (insulin, Glucophage, Glucotrol, Actos, DiaBeta, etc.)

Hoodia Gordonii – There are no known interactions with proper supplementation.

L-Carnitine – Acenocoumarol (blood thinner)

*Statements made herein have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

References

[1] Hummel M, Standl, E, Schnell, O. Chromium in metabolic and cardiovascular disease. Horm Metab Res. 2007 Oct;39(10):743-751.

[2] Broadhurst, CL, Domenico, P. Clinical studies on Chromium Picolinate supplementation in diabetes mellitus–a review. Diabetes Technol Ther. 2006 Dec; 8(6):677-687.

[3] Martin, J, Wang, ZQ, Zhang, XH, Wachtel, D, et al. Chromium Picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type 2 diabetes. Diabetes Care. 2006 Aug; 29(8):1826-1832.

[4] Wang, ZQ, Zhang, XH, et al. Chromium Picolinate enhances skeletal muscle cellular insulin signaling in vivo in obese, insulin-resistant JCR:LA-cp rats. J Nutr. 2006 Feb; 136(2):415-420.

[5] Shindea, UA, Sharma, G, Xu, YJ, et al. Insulin sensitising action of Chromium Picolinate in various experimental models of diabetes mellitus. J Trace Elem Med Biol. 2004; 18(1):23-32.

[6] Khan A, Safdar M, Khan MM, Khattak KN, & Anderson RA. Cinnamon Improves Glucose and Lipids of People With Type 2 Diabetes. Diabetes Care. 2003; 26:3215-3218.

[7] Ziegenfuss TN, Hofheins JE, Mendel RW, Landis J, Anderson RA. Effects of a water-soluble cinnamon extract on body composition and features of the metabolic syndrome in pre-diabetic men and women. J Int Soc Sports Nutr. 2006; 3:45-53.

[8] Hlebowicz J, Darwiche G, Bjorgell O, Almer LO. Effect of cinnamon on postprandial blood glucose, gastric emptying, and satiety in healthy subjects. American Journal of Clinical Nutrition. 2007; 85(6):1552-1556.

[9] Hyun, H., Hyun, S. H., & Choung, S. Y. Anti-diabetic effect of cinnamon extract on blood glucose in db/db mice Journal of Ethnopharmacology, 2006; 104(1/2):119-123.

[10] Qin B, Nagasaki M, Ren M, Bajotto G, Oshida Y, Sato Y. Cinnamon extract prevents the insulin resistance induced by a high-fructose diet. Horm Metab Res. 2004; 36(2):119-125.

[11] Hayamizu, K, Ishii, Y, Kaneko, I, et al. Effects of Garcinia Cambogia (Hydroxycitric Acid) on visceral fat accumulation: a double-blind, randomized, placebo-controlled trial. Current Therapeutic Research. 2003; 64(8):551-567.

[12] Asghar, M, Monjok, E, Kouamou, G, et al. Super CitriMax (HCA-SX) attenuates increases in oxidative stress, inflammation, insulin resistance, and body weight in developing obese Zucker rats. Mol Cell Biochem. 2007 Oct; 304(1-2):93-99.

[13] Shara, M, Ohia, SE, Schmidt, RE, Yasmin, T, et al. Physico-chemical properties of a novel -hydroxycitric acid extract and its effect on body weight, selected organ weights, hepatic lipid peroxidation and DNA fragmentation, hematology and clinical chemistry, and histopathological changes over a period of 90 days. Mol Cell Biochem. 2004 May; 260(1-2):171-186.

[14] Oluyemi, KA, Omotuyi, IO, Jimoh, OR, et al. Erythropoietic and anti-obesity effects of Garcinia Cambogia (bitter kola) in Wistar rats. Biotechnol Appl Biochem. 2007 Jan; 46(1):69-72.

[15] Venables, MC, Hulston, CJ, Cox, HR, Jeukendrup, AE. Green Tea extract ingestion, fat oxidation, and glucose tolerance in healthy humans. Am J Clin Nutr. 2008 Mar; 87(3):778-784.

[16] Nagao, T, Hase, T, Tokimitsu, I. A Green Tea extract high in catechins reduces body fat and cardiovascular risks in humans. Obesity. 2007 Jun; 15(6):1473-1483.

[17] Shimotoyodome, A, Haramizu, S, Inaba, M, et al. Exercise and Green Tea extract stimulate fat oxidation and prevent obesity in mice. Med Sci Sports Exerc. 2005 Nov; 37(11):1884-1892.

[18] Murase, T, Haramizu, S, et al. Green Tea extract improves endurance capacity and increases muscle lipid oxidation in mice. Am J Physiol Regul Integr Comp Physiol. 2005 Mar; 288(3):R708:715.

[19] Murase, T, Haramizu, S, et al. Green Tea extract improves running endurance in mice by stimulating lipid utilization during exercise. Am J Physiol Regul Integr Comp Physiol. 2006 Jun; 290(6):R1550-1556.

[20] Kanetkar, P, Singhal, R, Kamat, M. Gymnema sylvestre: A memoir. J Clin Biochem Nutr. 2007 Sep; 41(2):77-81.

[21] Sugihara, Y, Nojima, H, Matsuda, H, et al. Antihyperglycemic effects of gymnemic acid IV, a compound derived from Gymnema sylvestre leaves in streptozotocin-diabetic mice. J Asian Nat Prod Res. 2000; 2(4):321-327.

[22] Shigematsu, N, Asano, R, Shimosaka, M, Okazaki, M. Effect of administration with the extract of Gymnema sylvestre R. Br leaves on lipid metabolism in rats. Biol Pharm Bull. 2001 Jun; 24(6): 713-717.

[23] Luo, H, Kashiwagi, A, Shibahara, T, Yamada, K. Decreased bodyweight without rebound and regulated lipoprotein metabolism by gymnemate in genetic multifactor syndrome animal. Mol Cell Biochem. 2007 May; 299(1-2):93-98.

[24] Harada, S, Kasahara, Y. Inhibitory effect of gurmarin on palatal taste responses to amino acids in the rat. Am J Physiol Regul Integr Comp Physiol. 2000 Jun: 278(6): R1513-1517.

[25] Tulp, O,L, Harbi, N,A, Mihalov, J, Der Marderosian, A. Effect of Hoodia plant on food intake and body weight in lean and obese LA/Ntul//-cp rats. FASEB J. 2001 Mar 7; 15(4):A404.

[26] Van Heerden, FR, Marthinus, HR, Maharaj, VJ, et al. An appetite suppressant from Hoodia species. Phytochemistry. 2007 Oct; 68(20):2545-2553.

[27] Muller, DM, Seim, W, Kiess, HL, Richter, T. Effects of L-Carnitine supplementation on in vivo long-chain fatty acid oxidation in healthy adults. Metabolism. 2002; 51(11):1389-1391.

[28] Wutzke, H, Lorenz, H. The effect of L-Carnitine on fat oxidation, protein turnover, and body composition in slightly overweight subjects. Metabolism. 2004; 53(8):1002-1006.

Additional Information

Quantity	90
Day Supply	30