Forever HealthTM Adrenal Support contains key nutrients to support healthy adrenal function including: a bovine glandular blend, vitamin C, magnesium, zinc, manganese, selenium, citrus bioflavonoids, rhodiola rosea, ginseng, vitamin B5, magnolia bark, ashwagandha root, SerinAid®, and ginkgo biloba.
The bovine adrenal blend is formulated to support adrenal, hypothalamus, and pituitary function by stimulating the release of specific hormones that are necessary for optimum endocrine health. The adrenal, hypothalamus, and pituitary glands directly influence each other to support the stress response, immune system, mood, emotions, and several other body processes. This is also known as the hypothalamic-pituitary-adrenal axis (HPA axis). An HPA axis that is not functioning correctly can influence mood, stress, and overall health, as hormone sensitivity decreases., The hormones released by the HPA axis have been shown to effect physical energy, as cortisol and ACTH hormones were measured in 30 patients with chronic exhaustion ailments. Researchers found the irregular release of cortisol and ACTH hormones had an effect on health and physical energy.
Commonly used in Ayurvedic medicine to strengthen physical and mental stamina, ashwagandha is a nightshade plant native to India, Bangladesh, and Sri Lanka.
Ashwagandha can significantly improve antioxidant activity to lessen the formation of oxidative stress in the body. One study suggested ashwagandha had neuroprotective effects, as it produced a significant reduction in the proliferation of degenerating cells. Furthermore, ashwagandha can enhance cognition and memory that may be suppressed during stress, by aiding acetylcholine neurotransmitter function.
Ashwagandha’s adaptogenic activity can aid the stress response. A three-month study recruited 17 participants to take ashwagandha to see how the herb affected their ability to cope with stress. Researchers found that ashwagandha significantly improved subjects’ stress response, without adverse effects on the liver or kidneys.
Furthermore, ashwagandha was compared to a traditional cognitive medicine that is commonly used to alleviate social stress and anxiety. After six weeks of isolation, results indicated both ashwagandha and the traditional drug were effective in reducing anxiety and improving mood.
Citrus bioflavonoids have a direct antioxidant effect that can decrease the formation of oxidative stress in the brain, liver, and kidney tissue. ,, The antioxidant properties stabilize cellular membranes and scavenge free radicals to inhibit oxidative stress throughout the body.
Citrus bioflavonoids contain apigenin, a bioflavonoid that aids central nervous system function. An animal study administered apigenin to rats and mice with stress-related mood ailments, finding the bioflavonoid improved cognitive mechanisms related to normal stress levels.
Ginkgo biloba can decrease various hormone indicators commonly associated with acute or chronic stress, including elevated cortisol levels.  Researchers gave ginkgo biloba to rats and cortisol-producing cells, finding the nutrient reduced cortisol production in both the animal and cellular test. Another study found stress-related hormones were suppressed and learning behaviors improved in rats taking ginkgo biloba. Additionally, ginkgo biloba improves cathecholamines, norepinephrine and serotonin levels to reduce stress.
Stress can affect learning and memory function by releasing excessive amounts of glucocorticoid hormones, after a distressing event. This activity can impair cognitive function. Individuals with moderate memory impairment received 120 mg/day of ginkgo biloba for 3 to 6 months. Results indicated that subjects had greater cognitive function and improvement in coping with daily activities, especially when taken for 6 months. A recent study observed that ginkgo biloba prevented chronic stress to improve spatial memory function. Another behavioral study found ginkgo reduced corticosteroid levels that are elevated during stress by 50%.
As a phytoadaptogen, ginseng has a neuroprotective role that aids the cognitive mechanisms associated with neurological health. Several animal studies have found ginseng can prevent neuronal cell loss to protect the brain from oxidative damage and deter neurological ailments.,, Furthermore, ginseng may improve mood. A four-week study found ginseng aided mental health and social functioning, among elderly subjects whom reported an improvement in quality of life.
Ginseng has shown rapid improvements in cognitive function and fatigue in healthy, young volunteers during prolonged mental activity, suggesting ginseng can sustain mental alertness and energy.
Ginseng can also sustain the immune system during stress. An animal study gave ginseng to mice exerting large amounts of physical energy in a swimming test finding ginseng increased immune-supporting mechanisms.
Magnesium is an essential mineral for several body functions, including adrenal health. Magnesium deficiencies can disrupt mood, leading to greater anxiety and a poor disposition. Restoring magnesium levels through supplementation can quickly improve chronic mood ailments (less than seven days). Furthermore, a combination of zinc and magnesium alleviated stress-induced mood imbalances.
Magnesium supplementation can improve glucose utilization and the stress response. One study recruited competitive athletes to take magnesium or a placebo for four-weeks. Researchers found cortisol levels decreased, while energy and hormone metabolism improved to indicate optimal glucose utilization. Additionaly, magnesium may improve athletic performance, as it may aid energy metabolism and physical capacity.
Manganese is an essential trace mineral that can deter free radical production. Researchers found that 30-day manganese supplementation reduced lipid peroxidation in the adrenal glands. Manganese can reduce mood and pain ailments associated with women’s premenstrual cycle, as researchers found a combination of calcium and manganese supplementation reduced negative behavioral symptoms.
Magnolia bark has been used in traditional Chinese medicine for centuries to decrease physiological stress and improve mood. Researchers have found that magnolia bark, and other herbal aids, can support biochemical parameters related to mood ailments, suggesting the nutrients can improve disposition during stress. Additionally, magnolia bark can reduce oxidative stress and cortisol levels, as one study examined the effects of a nutritional formula containing magnolia bark on cortisol levels before, during, and after high-intensity resistance exercise. Researchers found that the supplement reduced free radical production and cortisol levels to enhance the exercise recovery process.
Pantothenic Acid, also known as vitamin B5, is essential to several metabolic functions, including the synthesis of steroid hormones, neurotransmitters, and lipids. Prolonged amounts of stress can affect the release of stress hormones, such as an elevation in cortisol levels. To support the adrenals and normal hormone function, the body needs B-vitamins, including pantothenic acid. Pantothenic acid can help alleviate systemic effects of stress.
B vitamins are essential to energy production; specifically, pantothenic acid is a precursor to important enzymes that provide optimal cellular energy to help your adrenals function normally. Furthermore, B vitamins inhibit the development of oxidative stress that can lead to accelerated aging. An animal study reviewed the effects of pantothenic acid on the adrenal glands, finding that supplementation stimulated adrenal sensitivity to release corticosterone and progesterone hormones that improve adrenal function.
A phospholipid derived from soy lecithin, SerinAid® (PS) is involved in distributing molecular messages between cells. It also balances elevated cortisol levels to help reduce stress, while improving cognitive function. One study found that PS improved hypothalamic-pituitary-adrenal (HPA) function to alleviate mood imbalances in elderly patients. A three-week study gave 20 subjects PS to determine the effects on mental distress. Findings suggested that PS improved the emotional response and decreased mental stress among individuals taking PS, when compared to the placebo group. PS supplementation was studied among 494 elderly patients with cognitive degeneration. Results showed significant improvement in behavioral and cognitive function among individuals taking PS.
PS can support memory function that can be deterred by stress and age-related cognitive ailments. A twelve-week study recruited 149 patients with memory ailments to take a PS formulation or a placebo. Memory and learning improved in subjects taking PS, as researchers suggested PS may discourage the development of cognitive ailments. An animal study reviewed the effects of PS on rat’s with memory ailments. Results indicated PS increased acetylcholine activity in the brain to stimulate memory function.
PS can affect cortisol levels during moderate-intensity exercise. Subjects that took PS for 10 days had lower cortisol levels, than the placebo group. Researchers concluded PS could inhibit physiological deterioration that is associated with exercise-induced stress.
Native to eastern Siberia, Rhodiola rosea has been used in Russian traditional medicine for centuries, as it is known for its adaptogenic activity (increases the body’s resistance to stress and aids mental function). Rhodiola’s adaptogenic activity relieves mental stress.  The extract can prevent behavioral and physiological changes that are often associated with chronic stress. Furthermore, a single dose of rhodiola has been shown to stimulate the central nervous system to balance mood and behavior.29
One study observed the effects of rhodiola extract on 56 healthy physicians that were suffering from fatigue during night shifts. After two weeks of rhodiola supplementation, the study found a significant improvement in energy levels among individuals taking the extract. Researchers suggested rhodiola can decrease fatigue during stressful conditions. Another study recruited students to take rhodiola for 20 days during an examination period. Results indicated students taking rhodiola had more physical and mental endurance, when compared to the placebo group.
A six-week study recruited individuals with mood ailments to take rhodiola extract, finding mood, sleep, and emotions improved in subjects taking rhodiola extract. Similarly, rhodiola may alleviate chronic anxiety, as a ten-week study demonstrated it significantly reduced anxiety among individuals taking the extract. Furthermore, the stress-relieving effects have been extended to stress-related cardiovascular ailments, as rhodiola can inhibit cardiovascular damage.
The endocrine system, including the adrenal glands and thyroid, contains high amounts of selenium to support proper endocrine function. Low levels of selenium have been linked to mood imbalances, such as anxiety, hostility, confusion, and a low disposition. An eight-week study measured selenium deficiencies in elderly subjects and observed the effect of selenium supplementation on their mood. The study found that individuals with low selenium serum levels had a significantly lower mood, whereas an increase in selenium improved disposition. Additionally, selenium improved mood in 30 healthy young men. Subjects felt more relaxed, confident, clear, and positive in the optimally dosed selenium group.
Selenium has a role in sustaining a healthy immune system, as a research review indicated micronutrient malnutrition may affect the hypothalamic-pituitary-adrenal axis that aids the immune response. Furthermore, selenium and other antioxidants can support high-energy sports performance, by inhibiting free radical damage associated with exercise and physiological stress. Researchers have suggested free radical damage can be reduced by supplementing with selenium, vitamin C, A, E, ginkgo biloba, and bioflavonoids.
The adrenal gland contains high amounts of vitamin C, which are depleted at a rapid rate, when the body is under stress. Vitamin C deficiencies can affect adrenal gland function, because the adrenal cortex is less protected against lipid peroxidation and free radical damage., Researchers examined the antioxidant effects of vitamin C, beta-carotene, and vitamin E supplementation among professional basketball players to understand their role on exercise stress markers. The study measured stress markers before supplementation, before training, after training and 24 hours after training. Supplementation decreased free radical formation and aided stress markers among athletes participating in strenuous physical exercise. Another study found that vitamin C supplementation stimulated circulating cortisol, adrenaline, and anti-inflammatory properties in ultra-marathon runners to support prolonged durations of stress.
Zinc is required for energy metabolism, as it is involved in several metabolic processes. Zinc levels can decline after strenuous physical stress leading to muscle fatigue and decreased immunity. Additionally, a zinc deficiency can increase anxiety-like behavior, as a two-week zinc deprivation study found the deficiency increased corticosterone and basal free calcium levels.
Eighty healthy male volunteers were recruited to take a supplement containing zinc, magnesium, and calcium, or a placebo, for 28 days to see how supplementation affected well-being. Subjects taking the vitamin supplement had a significant reduction in anxiety and perceived stress, when compared to the placebo group. Furthermore, subjects in the treatment group experienced more energy and mental concentration.
Additional Information – Dosage & Interactions
As a dietary supplement, take four capsules daily, or as directed by a physician.
Adrenal Blend – No typical dosage
Ashwangandha – Up to 6,000 mg per day
Calcium – Up to 1,200 mg per day
Citrus Bioflavonoids – Up to 1,000 mg per day
Ginkgo Biloba – 120 to 160 mg per day to aid circulation; 240 mg per day to improve cognitive abilities and balance mood
Ginseng – Up to 200 mg per day (2 mg eleutherosides)
Magnesium – Up to 350 mg per day
Magnolia Bark – Up to 750 mg per day
Manganese – Up to 10 mg per day
Pantothenic Acid – Typical dosage is 10 to 50 mg per day
Phosphatidylserine (SerinAid®) – 200 mg to 500 mg per day (elemental PS)
Rhodiola Rosea – Up to 300 mg per day (6 mg rosavins, 3 mg salidrosides)
Selenium – Up to 900 mcg per day
Vitamin C – Up to 3,000 mg daily
Zinc – Up to 30 mg per day
The maximum safe dosages of the nutrients in this formula have not been determined for children, pregnant or nursing women, or those with severe liver or kidney disease. As with all supplement regimens, please consult your physician prior to use.
Adrenal Blend – There are no known adverse reactions with proper supplementation.
Ashwangandha – Individuals with leukemia should avoid supplements with Ashwagandha.
Calcium – Taking calcium without food may increase the risk of kidney stones. Mild upset stomach has been reported with calcium supplementation.
Citrus Bioflavonoids – There are no known adverse reactions with proper supplementation.
Ginkgo Biloba – Occasional gastrointestinal upset, allergic skin reaction and headache. Ginkgo Biloba is not known to be toxic in high doses. Due to its blood thinning properties, care should be used by individuals with blood clotting problems or those taking anticoagulant medications.
Ginseng – Individuals with cardiovascular disease or diabetes (may lower blood glucose levels) should use caution when taking supplements with ginseng.
Magnesium – Diarrhea, nausea, or abdominal cramping have been reported in large doses. Pregnant women and nursing mothers should not take doses greater than 350 mg per day of magnesium. Individuals with myasthenia gravis should not take magnesium.
Magnolia Bark – There are no known adverse reactions with proper supplementation.
Manganese – Individuals with liver or kidney ailments should not take manganese.
Pantothenic Acid – Diarrhea may occur in large doses.
Phosphatidylserine (SerinAid®) – There are no known adverse reactions with proper supplementation.
Rhodiola Rosea – There are no known adverse reactions with proper supplementation.
Selenium – Pregnant women and nursing mothers should avoid taking doses greater than the RDA amount of selenium (60 to 70 mcg per day). Excessively high doses of selenium can lead to dry hair, brittle nails, fatigue, irritability, nausea, and vomiting.
Vitamin C – Stomach upset including nausea, diarrhea, abdominal cramps may occur in large doses due to unabsorbed vitamin C passing through the intestines.
Zinc – High doses of zinc can lead to copper deficiency or cause stomach upset.
Consult a physician before taking Adrenal Support, as the following key nutrients may interact with certain medications.
Adrenal Blend – There are no known interactions with proper supplementation.
Ashwangandha – Cyclophosphamide, Pentobarbital
Calcium – Bisphosphonates, H2 blockers, Levothyroxine, Proton pump inhibitors, Quinolones, Tertracyclines, Vitamin D Analogues.
Citrus Bioflavonoids – There are no known interactions with proper supplementation.
Ginkgo Biloba – Blood thinning medicine (Coumadin, Plavix, etc.); Pain Relievers (Advil, Motrin, etc.), Naproxen (Aleve, etc.); Anti-Depressants (Zoloft, Paxil, etc.); High blood pressure medicine (Cardizem, Cardene, etc.); Anti-convulsants (Dilantin, Tegretol, etc.); and/or Insulin.
Ginseng – Albendazole, Anticoagulants, Insulin, Estrogen, MAOIs, Nifedipine
Magnesium – Biphosphonates, Quinolones, Tetracyclines
Magnolia Bark – Barbiturates, Mood altering drugs
Manganese – Antacids, Laxatives, Tetracycline
Pantothenic Acid – There are no known interactions with proper supplementation.
Phosphatidylserine (SerinAid®) – There are no known interactions with proper supplementation.
Rhodiola Rosea – There are no known interactions with proper supplementation.
Selenium – There are no known interactions with proper supplementation.
Vitamin C – Aluminum-containing antacids, Aspirin (impairs vitamin C), Chemotherapeutic agents, Estrogen, or Indinavir.
Zinc – Antibiotics block zinc absorption
*Statements made herein have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
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